Journal article
The effects of terlipressin on regional hemodynamics and kidney function in experimental hyperdynamic sepsis
K Ishikawa, L Wan, P Calzavacca, R Bellomo, M Bailey, CN May
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Abstract
Background and Aims: Although terlipressin (TP) may improve renal function in cirrhotic patients, its use in sepsis remains controversial due to concerns about regional ischemia. We investigated the effects of TP on regional hemodynamics and kidney function in experimental hyperdynamic sepsis. Methods: We studied thirteen merino ewes in a university physiology laboratory using a randomized controlled cross over design. We implanted flow probes around the pulmonary, circumflex coronary, superior mesenteric, renal and iliac arteries. We injected live Escherichia coli and induced hyperdynamic sepsis. We treated animals with either bolus vehicle or a single dose of TP (sTP = 1 mg). In a second g..
View full abstractRelated Projects (2)
Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported by a grant from the National Health Medical Research Council (NHMRC), Australia (454615) and the Victorian Government's Operational Infrastructure Support Program. KI was supported by a research fellowship from Iwate Medical University, and CNM was supported by an NHMRC Research Fellowship (566819). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.